CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Zuclopenthixol
Clopixol
Use with caution
Your body clears this drug slowly, so it builds up in your blood. Half the usual dose is advised.
The genes behind this label
The guidelines read one gene for zuclopenthixol. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
DPWG guideline
Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your body clears this drug slowly, so it builds up in your blood. Half the usual dose is advised.
- What it means
- Markedly decreased CYP2D6 activity reduces conversion of zuclopenthixol, raising plasma concentration approximately 1.6-fold and elevating side effect risk.
- What the guideline suggests
- Use 50% of the normal dose.
About zuclopenthixol
Zuclopenthixol (Clopixol) is a first-generation antipsychotic of the thioxanthene type, used for psychoses, especially schizophrenia.
- Used for
- Psychoses, especially schizophrenia (not approved in the US)
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.