Is my medication affected by genetics?

Type a brand or generic drug name. We'll show you every active ingredient and which ones are affected by pharmacogenetic variants.

Looking for a GeneSight alternative? Compare → Have WGS or VCF data? See the WGS pharmacogenetics guide →

Browse by gene

Every pharmacogene affects a specific set of medications. See the full drug list for each gene.

CYP2D6
Cytochrome P450 2D6
45 drugs
CYP2C19
Cytochrome P450 2C19
21 drugs
CYP2C9
Cytochrome P450 2C9
16 drugs
SLCO1B1
Solute Carrier Organic Anion Transporter 1B1
7 drugs
UGT1A1
UDP Glucuronosyltransferase Family 1 Member A1
6 drugs
TPMT
Thiopurine S-Methyltransferase
3 drugs
NUDT15
Nudix Hydrolase 15
3 drugs
GLP1R
Glucagon-Like Peptide-1 Receptor
3 drugs
COMT
Catechol-O-Methyltransferase
3 drugs
CYP2B6
Cytochrome P450 2B6
3 drugs
IFNL3
Interferon Lambda 3 (formerly IL28B)
3 drugs
DPYD
Dihydropyrimidine Dehydrogenase
2 drugs
GIPR
Gastric Inhibitory Polypeptide Receptor
2 drugs
ABCG2
ATP-Binding Cassette Subfamily G Member 2 (BCRP)
2 drugs
BCHE
Butyrylcholinesterase
2 drugs
CYP1A2
Cytochrome P450 1A2
1 drug
VKORC1
Vitamin K Epoxide Reductase Complex Subunit 1
1 drug
CYP3A5
Cytochrome P450 3A5
1 drug
CYP3A4
Cytochrome P450 3A4
1 drug
ADH1B
Alcohol Dehydrogenase 1B
1 drug
AKT1
AKT Serine/Threonine Kinase 1
1 drug
ALDH2
Aldehyde Dehydrogenase 2
1 drug
CFTR
Cystic Fibrosis Transmembrane Conductance Regulator
1 drug
CHRNA5
Cholinergic Receptor Nicotinic Alpha 5 Subunit
1 drug
CYP2A6
Cytochrome P450 2A6
1 drug
CYP4F2
Cytochrome P450 4F2
1 drug
FAAH
Fatty Acid Amide Hydrolase
1 drug
GCGR
Glucagon Receptor
0 drugs

Browse by drug class

Therapeutic classes with published pharmacogenetic guidelines.

Chemotherapy agents
12 drugs
Pain medications
12 drugs
Antipsychotics
11 drugs
Tricyclic antidepressants
7 drugs
Statins
7 drugs
Other substances
7 drugs
SSRI antidepressants
6 drugs
Anticonvulsants
4 drugs
Proton pump inhibitors
4 drugs
Immunosuppressants
4 drugs
Antiemetics
4 drugs
Antivirals
3 drugs
Movement disorder medications
3 drugs
Weight management (GLP-1 agonists)
3 drugs
Gout treatment
1 drug

Browse by guidance source

Every recommendation traces to a published source. See how each organization works and every drug it covers.

FDA
U.S. Food and Drug Administration
65 drugs
CPIC
Clinical Pharmacogenetics Implementation Consortium
56 drugs
Gene2Rx
Gene2Rx curated guidance
10 drugs
DPWG
Dutch Pharmacogenetics Working Group
4 drugs

How this works

  1. Many medications are combo products: Excedrin is acetaminophen + aspirin + caffeine; Vyvanse is a prodrug of dextroamphetamine; Fioricet contains butalbital, acetaminophen, and caffeine.
  2. When you search, we resolve the product to its active ingredients and check each against published pharmacogenetic guidelines (CPIC, FDA).
  3. If an ingredient is affected by a specific gene (CYP2D6, CYP2C19, SLCO1B1, etc.), we flag it with the strongest evidence level we have and link to the full drug page.
  4. "Not in database" means no strong published PGx guideline for that ingredient — not that genetics play no role. Evidence grows every year.

Find out your specific drug response

This lookup is generic. A Gene2Rx report tells you how your individual genetics affect each medication.

Get your report

Informational tool only. "Not in database" means no strong published pharmacogenetic guideline for that ingredient, not that genetics play no role. Never start, stop, or change a medication without talking to your prescribing clinician.

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