HLA-B

Drugs affected by HLA-B

Human Leukocyte Antigen B

4 medications 4 brand products

About HLA-B

HLA-B variants don't affect how drugs are metabolized. They affect your immune system's reaction to them. Specific HLA-B alleles are strongly linked to severe skin reactions to drugs like abacavir (HIV), carbamazepine (seizures, bipolar), and allopurinol (gout).

Screening for HLA-B*57:01 before abacavir, and HLA-B*15:02 before carbamazepine in at-risk populations, is now standard of care in much of the world.

Medications with HLA-B guidelines

Gene2Rx covers 4 medications with published pharmacogenetic guidance for HLA-B, drawn from CPIC and FDA sources. Each drug links to its full pharmacogenetics page.

anticonvulsants →

Carbamazepine FDA Fosphenytoin CPIC / FDA Phenytoin CPIC / FDA

antiretrovirals

Abacavir FDA

Brand products containing a HLA-B-affected ingredient

These branded medications include at least one active ingredient whose metabolism or action involves HLA-B. Each links to its full pharmacogenetic breakdown.

Find out your personal HLA-B phenotype

This page lists drugs affected by HLA-B. A Gene2Rx report tells you which metabolizer group you fall into, and what that means for every medication on this list.

Get your report Look up a medication

Informational only, not medical advice. The presence of a HLA-B pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.