Genetics-Driven Drug Guidance in Minutes

Gene2Rx analyzes your DNA and detects genetic variations that may lead to an atypical response to 111 medications, including antidepressants, pain medication, statins, alcohol, and other recreational drugs, among others. Each drug has guidance provided by the Food and Drug Administration or the Clinical Pharmacogenomics Implementation Consortium (CPIC). See here for a full list of analyzed medications.

Do not alter your medication dosage or stop taking your medication without first consulting your healthcare provider. Direct-to-consumer data is not clinical grade, so anything included in the report should be used as a conversation starter with your healthcare provider to seek the appropriate clinical laboratory test. Again, do not alter your medication dosage or stop taking your medication without first consulting your healthcare provider.

Our service relies on the genetic information provided to you by the direct-to-consumer service you paid for. Unfortunately, direct-to-consumer data is not clinical grade, so anything included in the report should be used as a conversation starter with your healthcare provider to seek the appropriate clinical laboratory test. DO NOT alter your medication dosage or stop taking your medication without first consulting your healthcare provider. Read more here and read primary research here.

Yes. For each drug included in the report either the FDA, CPIC, or both have deemed the evidence of a drug-gene interaction sufficient to provide clinical prescription guidance based on an individual's genetics. The Clinical Pharmacogenetics Implementation Consortium (CPIC) is a group of PGx experts that volunteer their time to curate genetic guidance for drug response, based on the most recent research. They have high standards for the evidence required to include a drug-gene guideline. You can read more about this organization on their website.

Consumer genotyping arrays: Among 23andMe, AncestryDNA, MyHeritage, and TellMeGen, we recommend 23andMe. It directly measures more of the pharmacogenomically relevant variants, and our annotations perform best against 23andMe data based on internal validation.

Whole genome sequencing (WGS): Gene2Rx accepts VCF files from any WGS provider. Popular services include Nebula Genomics, Dante Labs, Sequencing.com, Nucleus Genomics, DNA Complete, and Veritas. If you have a 30x WGS VCF on hand — from any provider — you can upload it directly. WGS offers broader, higher-confidence variant coverage than consumer arrays and is our recommended input for the most accurate pharmacogenetics results.

Gene2Rx supports two categories of input:

Consumer genotyping arrays — download your raw data file:
• 23andMe: Download instructions
• AncestryDNA: Download instructions
• MyHeritage: Download instructions
• TellMeGen: Download instructions

Whole Genome Sequencing (WGS) VCF — upload directly:
We accept .vcf and .vcf.gz files from any WGS provider. The genome build (GRCh38 or GRCh37) is auto-detected from the VCF header. Popular providers include:
• Nebula Genomics
• Dante Labs
• Sequencing.com
• Nucleus Genomics
• DNA Complete, Veritas, and any other provider that delivers a standard VCF

A $15 WGS processing surcharge applies per report type.

Yes! Gene2Rx provides direct-to-consumer pharmacogenetics testing using your existing 23andMe, AncestryDNA, MyHeritage, or TellMeGen genetic data — or a Whole Genome Sequencing (WGS) VCF file. No doctor visit, prescription, or healthcare provider authorization required. Simply upload your genetic data file and get your report in minutes.

Unlike GeneSight and Genomind, Gene2Rx doesn't require a doctor's prescription or healthcare provider authorization. You get results in minutes (not weeks), test 111 medications (not just psychiatric drugs), and pay transparent pricing ($5-$49) without insurance complications. GeneSight and Genomind focus primarily on mental health medications, while Gene2Rx covers pain, cardiac, psychiatric, and many other drug classes. See the full side-by-side comparison →

Yes! Check out our example reports to see if Gene2Rx is right for you. Each pricing option includes a link to view a sample report.

Yes. We offer a pharmacogenomic annotation API for bulk and high-volume data processing, anchored to CPIC and FDA guidance. See our API & Bulk Annotation page, or contact us at support@gene2rx.com.