Vitamin K Epoxide Reductase Complex Subunit 1
VKORC1 is warfarin's molecular target. A common promoter variant determines how much VKORC1 your liver produces, and therefore how much warfarin it takes to block the vitamin K cycle enough to thin your blood.[1]
Gene2Rx uses definitions covering 2 named VKORC1 alleles, built from 1 variant in Gene2Rx definitions. Results depend on the variants available in your upload.
VKORC1 alleles are named by the underlying DNA variant rather than a star number. For example, c.61C>T describes a single base change at position 61 of the coding sequence.
DNA variant labels identify sequence differences. Their interpretation depends on the particular gene, the evidence, and the variants that can be assessed in your data. A DNA result does not directly measure enzyme activity.
The source of these definitions is listed above. Missing variants or incomplete coverage can leave a result indeterminate.
This list contains 1 medication with VKORC1 information from the sources shown below. Evidence and report eligibility differ by drug; each page explains its scope and limitations.
These branded medications include at least one active ingredient whose metabolism or action involves VKORC1. Each links to its full pharmacogenetic breakdown.
A Gene2Rx report interprets supported variants in the context of your data and purchased report. Missing or uncertain calls may prevent an assessment.
Get your report Look up a medicationInformational only, not medical advice. The presence of a VKORC1 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.