Solute Carrier Organic Anion Transporter 1B1
SLCO1B1 is the transporter that moves statins into liver cells where they work. A common variant (called *5) reduces transporter function and leaves more statin circulating in the bloodstream and muscle tissue.[1] That's directly linked to statin-associated muscle pain and, rarely, more serious muscle damage.[2]
Gene2Rx reports your SLCO1B1 genotype across 36 named star alleles, built from 29 variants curated by PharmVar.
Star alleles (like *1, *2, *4) are standardized names for distinct versions of a pharmacogene. *1 is the reference; higher numbers identify variants discovered later that change the enzyme's activity.
You inherit one allele from each parent, so your genotype is a pair (e.g. *1/*4). The pair determines your predicted phenotype — for example, whether you metabolize a drug at a normal, decreased, or no-function rate.
PharmVar is the international registry that defines and curates these allele names. Gene2Rx tests the variants required to call every SLCO1B1 allele in the PharmVar catalog.
Gene2Rx covers 7 medications with published pharmacogenetic guidance for SLCO1B1, drawn from CPIC and FDA sources. Each drug links to its full pharmacogenetics page.
These branded medications include at least one active ingredient whose metabolism or action involves SLCO1B1. Each links to its full pharmacogenetic breakdown.
This page lists drugs affected by SLCO1B1. A Gene2Rx report tells you which metabolizer group you fall into, and what that means for every medication on this list.
Get your report Look up a medicationInformational only, not medical advice. The presence of a SLCO1B1 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.