Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Brexpiprazole

Rexulti

Use with caution

Your body clears brexpiprazole slowly, so more of it builds up. Half the usual dose is advised.

The genes behind this label

The guidelines read one gene for brexpiprazole. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer

DPWG guideline

In plain words: Your body clears brexpiprazole slowly, so more of it builds up. Half the usual dose is advised.
What it means: Decreased CYP2D6 activity reduces the metabolism of brexpiprazole, so the risk of side effects is theoretically increased.
What the guideline suggests: Use half of the normal dose.

FDA drug label

In plain words: Your body breaks down brexpiprazole much more slowly than normal, causing the drug to build up in your system. A lower dose is recommended to reduce the risk of side effects.
What it means: Results in higher systemic concentrations. Dosage adjustment is recommended. Refer to FDA labeling for specific dosing recommendations.
What the label suggests: Adjust the dosage as the FDA label directs for CYP2D6 poor metabolizers.

Brexpiprazole (Rexulti) is an antipsychotic used for schizophrenia, as an add-on treatment for depression, and for agitation in Alzheimer's dementia.

Used for: Schizophrenia (adults and adolescents 13 and older); add-on treatment for major depressive disorder in adults; agitation associated with dementia due to Alzheimer's disease

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.