CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Pimozide
Orap
Use with caution
Your body clears pimozide slowly, which could raise the risk of heart rhythm side effects. Half the usual maximum dose is advised.
The genes behind this label
The guidelines read one gene for pimozide. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
DPWG guideline
Use with caution Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your body clears pimozide slowly, which could raise the risk of heart rhythm side effects. Half the usual maximum dose is advised.
- What it means
- Decreased CYP2D6 activity raises the plasma concentration of pimozide, which theoretically increases the risk of QT prolongation and torsade de pointes. Following the dose limit offsets this.
- What the guideline suggests
- Use no more than the following doses (50% of the normal maximum dose): 12 years and older, 10 mg/day; younger than 12 years, 0.05 mg/kg per day to a maximum of 2 mg/day.
FDA drug label
Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down pimozide more slowly than normal, causing higher levels of the drug in your system. A lower dose is recommended to reduce the risk of side effects.
- What it means
- Results in higher systemic concentrations. Dosages should not exceed 0.05 mg/kg in children or 4 mg/day in adults who are poor metabolizers and dosages should not be increased earlier than 14 days.
- What the label suggests
- Do not exceed 0.05 mg/kg a day in children or 4 mg a day in adults, and do not increase the dose earlier than 14 days.
About pimozide
Pimozide (Orap) is an antipsychotic used in the US to suppress motor and vocal tics in Tourette's disorder when standard treatment has not worked.
- Used for
- Suppressing motor and phonic tics in Tourette's disorder that has not responded to standard treatment
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.