CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Haloperidol
Haldol
Use with caution
Your body clears haloperidol slowly, which raises the concentration in your blood and increases side effect risk. A lower dose is typically recommended.
The genes behind this label
The guidelines read one gene for haloperidol. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
DPWG guideline
Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your body clears haloperidol slowly, which raises the concentration in your blood and increases side effect risk. A lower dose is typically recommended.
- What it means
- Decreased CYP2D6 activity reduces conversion of haloperidol, increasing plasma concentration approximately 1.7-fold. This is associated with an increased risk of side effects.
- What the guideline suggests
- Use 60% of the normal dose.
About haloperidol
Haloperidol (Haldol) is a first-generation antipsychotic used for psychotic disorders and for the tics of Tourette's disorder.
- Used for
- Psychotic disorders, including schizophrenia; tics and vocal utterances of Tourette's disorder; some severe behavior problems in children
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.