CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Clozapine
Clozaril
Use with caution
Your body breaks down clozapine much more slowly than normal, causing the drug to build up to higher levels in your system. A lower dose may be needed to reduce the risk of side effects.
The genes behind this label
The guidelines read one gene for clozapine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
DPWG guideline
Use as directed Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your CYP2D6 result does not change how clozapine should be dosed.
- What it means
- CYP2D6 variation can change clozapine blood levels, but this has no clinical consequences.
- What the guideline suggests
- No action is required. Use standard clozapine dosing.
FDA drug label
Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down clozapine much more slowly than normal, causing the drug to build up to higher levels in your system. A lower dose may be needed to reduce the risk of side effects.
- What it means
- Results in higher systemic concentrations. Dosage reductions may be necessary.
- What the label suggests
- Dosage reductions may be necessary.
About clozapine
Clozapine (Clozaril) is an antipsychotic for schizophrenia that has not responded to other treatments, and for lowering the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder.
- Used for
- Treatment-resistant schizophrenia; reducing the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.