CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Aripiprazole
Abilify
Use with caution
Your body clears aripiprazole slowly, so more of it builds up and side effects are more likely. A lower maximum dose is advised.
The genes behind this label
The guidelines read one gene for aripiprazole. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
DPWG guideline
Use with caution Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your body clears aripiprazole slowly, so more of it builds up and side effects are more likely. A lower maximum dose is advised.
- What it means
- Decreased CYP2D6 activity raises the combined blood level of aripiprazole and its active metabolite, increasing the risk of side effects.
- What the guideline suggests
- Administer no more than 10 mg/day, 300 mg/month or 720 mg/2 month (68-75% of the standard maximum dose of aripiprazole).
FDA drug label
Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down aripiprazole much more slowly than normal, causing the drug to build up and increasing the risk of side effects. A lower dose is recommended.
- What it means
- Results in higher systemic concentrations and higher adverse reaction risk. Dosage adjustment is recommended. Refer to FDA labeling for specific dosing recommendations.
- What the label suggests
- Adjust the dosage as the FDA label directs for CYP2D6 poor metabolizers.
About aripiprazole
Aripiprazole (Abilify) is an antipsychotic used for schizophrenia, bipolar mania, Tourette's disorder and irritability in autism, and as an add-on treatment for depression.
- Used for
- Schizophrenia; manic and mixed episodes of bipolar I disorder; add-on treatment for major depressive disorder; irritability with autistic disorder; Tourette's disorder. The injections are for schizophrenia and maintenance treatment of bipolar I disorder in adults.
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.