Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Antidepressants · SSRIsExample report

Vortioxetine

Trintellix, Brintellix

Use with caution

Your body clears this drug much more slowly. Half the usual starting dose is advised, or a different antidepressant.

The genes behind this label

The guidelines read one gene for vortioxetine. Each card shows the two copies this person inherited and what they mean.

CYP2D6*4/*4

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Poor metabolizer

CPIC guideline

Use with caution Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body clears this drug much more slowly. Half the usual starting dose is advised, or a different antidepressant.
What it means: Greatly reduced metabolism of vortioxetine to inactive compounds compared with normal metabolizers. Higher plasma concentrations may increase the probability of side effects.
What the guideline suggests: Initiate 50% of starting dose (e.g., 5 mg) and titrate to the maximum recommended dose of 10 mg or consider a clinically appropriate alternative antidepressant not predominantly metabolized by CYP2D6.

FDA drug label

Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body breaks down vortioxetine much more slowly than normal, causing the drug to build up to higher levels. A lower maximum dose is recommended to reduce the risk of side effects.
What it means: Results in higher systemic concentrations. The maximum recommended dose is 10 mg.
What the label suggests: The maximum recommended dose is 10 mg.

About vortioxetine

Vortioxetine (Trintellix) is an antidepressant for major depressive disorder in adults that blocks serotonin reuptake and also acts on several serotonin receptors.

Used for: Major depressive disorder in adults (the FDA-labeled use)

Others in antidepressants

Compare all 14 antidepressants

And 5 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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