CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Antidepressants · SSRIsExample report
Sertraline
Zoloft
Use with caution
Your body processes this drug a bit more slowly. You can start at the usual dose, but your doctor may raise it slowly, and a lower ongoing dose may be enough.
The genes behind this label
The guidelines read 2 genes for sertraline. Each card shows the two copies this person inherited and what they mean.
CYP2B6Your two copies: *1/*1
Normal metabolizer
Both copies work normally.
Breaks down efavirenz, ketamine, methadone and some drugs for depression.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizerCYP2B6Normal metabolizer
CPIC guideline, both genes together
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body processes this drug a bit more slowly. You can start at the usual dose, but your doctor may raise it slowly, and a lower ongoing dose may be enough.
- What it means
- CYP2C19: Reduced metabolism of sertraline to less active compounds when compared to CYP2C19 normal metabolizers. CYP2B6: Normal metabolism of sertraline to less active compounds.
- What the guideline suggests
- Initiate therapy with recommended starting dose. Consider a slower titration schedule and lower maintenance dose.
From the combined CYP2C19 and CYP2B6 table in CPIC's guideline for serotonin reuptake inhibitor antidepressants.
CPIC reads your CYP2C19 and CYP2B6 results together for sertraline, so this label reflects both genes.
About sertraline
Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI) antidepressant used for depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder and premenstrual dysphoric disorder.
- Used for
- Major depressive disorder, obsessive-compulsive disorder (also in children 6 and older), panic disorder, post-traumatic stress disorder, social anxiety disorder, premenstrual dysphoric disorder
Others in antidepressants
Compare all 14 antidepressants- CitalopramCelexa Use with caution
- EscitalopramLexapro Use with caution
- FluvoxamineLuvox Use with caution
- ParoxetinePaxil, Seroxat Use with caution
- VortioxetineTrintellix, Brintellix Use with caution
- VenlafaxineEffexor XR Consider alternative
- AmitriptylineElavil Consider alternative
- ClomipramineAnafranil Consider alternative
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.