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Antidepressants · SSRIsExample report

Escitalopram

Lexapro

Use with caution

Your body may break down the drug more slowly, increasing side effects. Your doctor may use a lower dose or adjust it more slowly.

The genes behind this label

The guidelines read one gene for escitalopram. Each card shows the two copies this person inherited and what they mean.

CYP2C19*1/*2

Intermediate metabolizer

One copy works and one doesn't.

Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2C19Intermediate metabolizer

CPIC guideline

Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)

In plain words: Your body may break down the drug more slowly, increasing side effects. Your doctor may use a lower dose or adjust it more slowly.
What it means: Reduced metabolism when compared with CYP2C19 normal metabolizers. Higher plasma concentrations may increase the probability of side effects.
What the guideline suggests: Initiate therapy with recommended starting dose. Consider a slower titration schedule and lower maintenance dose than normal metabolizers.

About escitalopram

Escitalopram (Lexapro) is a selective serotonin reuptake inhibitor (SSRI) antidepressant used for major depressive disorder and generalized anxiety disorder.

Used for: Major depressive disorder in adults and adolescents 12 and older; generalized anxiety disorder in adults and children 7 and older

Others in antidepressants

Compare all 14 antidepressants

And 5 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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