Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Antidepressants · SNRIsExample report

Venlafaxine

Effexor XR

Consider alternative

Your body breaks down this drug much more slowly, which has been linked to more side effects. A different antidepressant may be a better choice.

The genes behind this label

The guidelines read one gene for venlafaxine. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer

CPIC guideline

In plain words: Your body breaks down this drug much more slowly, which has been linked to more side effects. A different antidepressant may be a better choice.
What it means: Decreased metabolism of venlafaxine to the active metabolite O-desmethylvenlafaxine and greatly decreased O-desmethylvenlafaxine:venlafaxine ratio compared with normal and intermediate metabolizers. Although the clinical impact is unclear, poor metabolizer status has been associated with adverse effects.
What the guideline suggests: Consider a clinically appropriate alternative antidepressant not predominantly metabolized by CYP2D6.

FDA drug label

In plain words: Your body breaks down venlafaxine much more slowly than normal, causing the drug to build up in your system. A lower dose may be needed to avoid side effects.
What it means: Alters systemic parent drug and metabolite concentrations. Consider dosage reductions.
What the label suggests: Consider dosage reductions.

Venlafaxine (Effexor XR) is a serotonin and norepinephrine reuptake inhibitor (SNRI) used for depression and three anxiety disorders.

Used for: Major depressive disorder, generalized anxiety disorder, social anxiety disorder and panic disorder in adults

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.