CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Antidepressants · SSRIsExample report
Citalopram
Celexa
Use with caution
Your body may break down the drug more slowly, increasing side effects. Your doctor may use a lower dose or adjust it more slowly.
The genes behind this label
The guidelines read one gene for citalopram. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizer
CPIC guideline
Use with caution Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body may break down the drug more slowly, increasing side effects. Your doctor may use a lower dose or adjust it more slowly.
- What it means
- Reduced metabolism when compared with CYP2C19 normal metabolizers. Higher plasma concentrations may increase the probability of side effects.
- What the guideline suggests
- Initiate therapy with recommended starting dose. Consider a slower titration schedule and lower maintenance dose than normal metabolizers.
FDA drug label
Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down citalopram slightly slower than normal. The standard dose should work as expected.
- What it means
- No FDA guidance for your genotype
- What the label suggests
- Initiate therapy with recommended starting dose.
About citalopram
Citalopram (Celexa) is a selective serotonin reuptake inhibitor (SSRI) antidepressant, approved in the US for major depressive disorder in adults.
- Used for
- Major depressive disorder in adults. Not approved for children.
Others in antidepressants
Compare all 14 antidepressants- EscitalopramLexapro Use with caution
- FluvoxamineLuvox Use with caution
- ParoxetinePaxil, Seroxat Use with caution
- SertralineZoloft Use with caution
- VortioxetineTrintellix, Brintellix Use with caution
- VenlafaxineEffexor XR Consider alternative
- AmitriptylineElavil Consider alternative
- ClomipramineAnafranil Consider alternative
Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.