Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Antidepressants · SSRIsExample report

Fluvoxamine

Luvox

Use with caution

Your body breaks down this drug much more slowly. A lower starting dose, a slower increase, or a different drug may be safer.

The genes behind this label

The guidelines read one gene for fluvoxamine. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer

CPIC guideline

In plain words: Your body breaks down this drug much more slowly. A lower starting dose, a slower increase, or a different drug may be safer.
What it means: Greatly reduced metabolism of fluvoxamine to less active compounds compared with normal metabolizers. Higher plasma concentrations may increase the probability of side effects.
What the guideline suggests: Consider a 25 to 50% lower starting dose and slower titration schedule as compared with normal metabolizers or consider a clinically appropriate alternative antidepressant not predominantly metabolized by CYP2D6.

Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) approved in the US for obsessive-compulsive disorder (OCD).

Used for: Obsessive-compulsive disorder in adults and in children and adolescents aged 8 to 17 (the FDA-labeled use)

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.