Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Antidepressants · SSRIsExample report

Paroxetine

Paxil, Seroxat

Use with caution

Your body processes this drug very slowly, so you may need half the usual dose to avoid side effects.

The genes behind this label

The guidelines read one gene for paroxetine. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer

CPIC guideline

In plain words: Your body processes this drug very slowly, so you may need half the usual dose to avoid side effects.
What it means: Greatly reduced metabolism compared with CYP2D6 normal metabolizers. Higher plasma concentrations may increase the probability of side effects.
What the guideline suggests: Consider a 50% reduction in recommended starting dose, slower titration schedule, and a 50% lower maintenance dose as compared with normal metabolizers.

Paroxetine (Paxil) is a selective serotonin reuptake inhibitor (SSRI) used for depression and several anxiety disorders.

Used for: Major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder and post-traumatic stress disorder in adults

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.