CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Thioridazine
Mellaril
Consider alternative
Your body breaks down thioridazine much too slowly, causing dangerous levels to build up. This significantly increases your risk of serious heart rhythm problems. This medication should not be used.
The genes behind this label
The guidelines read one gene for thioridazine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
FDA drug label
Evidence: strongSee the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down thioridazine much too slowly, causing dangerous levels to build up. This significantly increases your risk of serious heart rhythm problems. This medication should not be used.
- What it means
- Results in higher systemic concentrations and higher adverse reaction risk (QT prolongation). Predicted effect based on experience with CYP2D6 inhibitors. Contraindicated in poor metabolizers.
- What the label suggests
- Do not use thioridazine. It is contraindicated for poor metabolizers due to dangerous heart rhythm risks.
About thioridazine
Thioridazine (Mellaril) is an older phenothiazine antipsychotic that is reserved for schizophrenia that has not responded to other antipsychotics.
- Used for
- Schizophrenia that has not responded adequately to other antipsychotics
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.