CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
AntipsychoticsExample report
Risperidone
Risperdal
Use with caution
Your body clears risperidone slowly, so more of it builds up and side effects are more likely. About two-thirds of the usual dose is advised, and less if side effects still occur.
The genes behind this label
The guidelines read one gene for risperidone. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
DPWG guideline
Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)
- In plain words
- Your body clears risperidone slowly, so more of it builds up and side effects are more likely. About two-thirds of the usual dose is advised, and less if side effects still occur.
- What it means
- Decreased CYP2D6 activity raises the combined blood level of risperidone and its active metabolite, and a larger share of it is risperidone, which enters the brain more easily. The share of patients with therapy failure rises from 16% to 26%.
- What the guideline suggests
- Use 67% of the normal dose. If problematic side effects originating in the central nervous system occur despite this reduced dose, then reduce the dose further to 50% of the normal dose.
About risperidone
Risperidone (Risperdal) is a second-generation antipsychotic used for schizophrenia, bipolar mania and irritability associated with autism.
- Used for
- Schizophrenia; manic or mixed episodes of bipolar I disorder; irritability associated with autistic disorder
Others in antipsychotics
Compare all 12 antipsychoticsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.