AKT1Your two copies: rs2494732C/rs2494732T
CTDecreased function
A signaling gene linked to the risk of psychosis with heavy cannabis use.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Other substancesExample report
THC
Cannabis, Marijuana
Use with caution
You may be more likely to feel anxious or paranoid on THC. Starting with a lower dose can help.
The genes behind this label
The guidelines read 4 genes for THC. Each card shows the two copies this person inherited and what they mean.
COMTYour two copies: rs4680A/rs4680G
Intermediate function
One copy works and one works less well.
Breaks down dopamine and other brain chemicals.
This result doesn't change the label.
CYP2C9Your two copies: *1/*2
Intermediate metabolizer
One copy works and one works less well.
1.5 activity scoreTypical: 2Clears warfarin, phenytoin, celecoxib and some other pain relievers.
This result doesn't change the label.
FAAHYour two copies: rs324420C/rs324420C
Normal function
Both copies work normally.
Breaks down chemicals your body makes that act like cannabis.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
AKT1Decreased function
Gene2Rx research summary
Use with caution Evidence: weakSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- You may be more likely to feel anxious or paranoid on THC. Starting with a lower dose can help.
- What it means
- One rs2494732 C allele. In a case-control study of first-episode psychosis the variant was not associated with psychosis, cannabis use or frequency of use on its own, but modified the association between cannabis use and psychotic disorder, and acute psychotomimetic symptoms rose with C-allele count in cannabis users. A later study of 720 people found no such association.
- What the research suggests
- Some research suggests that carriers of this variant may have a moderately higher risk of psychotic-like effects from THC. However these findings are not conclusive. Consider starting at a lower dose and monitoring for psychotic-like effects or avoiding THC altogether.
COMTIntermediate function
Gene2Rx research summary
Use as directed Evidence: weakSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your genes point to a typical response to THC, with an average chance of side effects.
- What it means
- One rs4680 G and one A allele (Val158/Met158). Intermediate COMT activity and average dopamine clearance.
- What the research suggests
- No COMT-based adjustment. A typical response to THC is expected.
CYP2C9Intermediate metabolizer (activity score 1.5)
Gene2Rx research summary
Use as directed Evidence: weakSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your body may break down THC slightly more slowly than average, so effects could feel a little stronger or last a little longer.
- What it means
- Activity score 1.5 (one decreased-function allele, usually *2). Slightly reduced hydroxylation of THC. In the only published pharmacokinetic study of oral THC by CYP2C9 genotype, *2 status alone did not change THC exposure, so any increase at this activity score is expected to be small.
- What the research suggests
- Initiate at standard doses. Monitor for increased sedation or psychotropic intensity.
FAAHNormal function
Gene2Rx research summary
Use as directed Evidence: moderateSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- This gene works normally, so THC should affect you in the usual way.
- What it means
- Two rs324420 C alleles (Pro129). Usual hydrolysis of anandamide and related endocannabinoids, so baseline cannabinoid receptor tone is typical. FAAH does not metabolize THC.
- What the research suggests
- No FAAH-based adjustment. Response to THC is expected to match population norms.
About THC
THC is the main psychoactive compound in cannabis and the active ingredient of the prescription medicine dronabinol.
- Used for
- As dronabinol: chemotherapy-induced nausea and vomiting that has not responded to other treatment, and appetite loss in AIDS-related weight loss. Cannabis is also used medically under state programs and non-medically.
Others in other substances
Compare all 7 other substancesDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.