AKT Serine/Threonine Kinase 1
AKT1 sits in the signaling pathway downstream of dopamine receptors in the brain. A common variant near the gene (rs2494732) has been linked, in several observational studies, to a higher risk of psychotic symptoms in people who use cannabis. The effect is modest and not deterministic, but it's part of why cannabis affects some users very differently than others.
Gene2Rx reports your AKT1 genotype across 2 named alleles, built from 1 variant curated by PharmVar.
AKT1 alleles are named by the underlying DNA variant rather than a star number — for example c.61C>T describes a single base change at position 61 of the coding sequence.
You inherit one allele from each parent, and the pair determines whether your AKT1 activity is normal, decreased, or absent.
PharmVar is the international registry that curates these names. Gene2Rx tests every variant needed to call each cataloged AKT1 allele.
Gene2Rx covers 1 medication with published pharmacogenetic guidance for AKT1, drawn from CPIC and FDA sources. Each drug links to its full pharmacogenetics page.
This page lists drugs affected by AKT1. A Gene2Rx report tells you which metabolizer group you fall into, and what that means for every medication on this list.
Get your report Look up a medicationInformational only, not medical advice. The presence of a AKT1 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.