ADH1BYour two copies: rs1229984C/rs1229984C
Normal function
Both copies work normally.
Turns alcohol into acetaldehyde, a toxic by-product.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Other substancesExample report
Alcohol
Use as directed
Your genes have little effect on how your body handles alcohol.
The genes behind this label
The guidelines read 2 genes for alcohol. Each card shows the two copies this person inherited and what they mean.
ALDH2Your two copies: rs671G/rs671G
Normal function
Both copies work normally.
Clears acetaldehyde, the toxic by-product of alcohol.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
ADH1BNormal function
Gene2Rx research summary
Use as directed See the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your genes have little effect on how your body handles alcohol.
- What it means
- Two Arg48 alleles (rs1229984). Usual rate of ethanol oxidation. Compared with His48 carriers, associated with higher risk of alcohol dependence and, among heavy drinkers in East Asian studies, higher risk of esophageal and head and neck cancer. Only rs1229984 is assessed: ADH1B*3 (rs2066702), common in people of African ancestry, is not read, so its carriers are reported here.
- What the research suggests
- Follow standard guidelines for alcohol consumption.
ALDH2Normal function
Gene2Rx research summary
Use as directed See the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your genes have little effect on how you clear the toxic by-product of alcohol.
- What it means
- Two Glu504 alleles (rs671 G/G, ALDH2*1/*1). Normal acetaldehyde clearance; typical risk of flushing, hangover and alcohol dependence for this gene.
- What the research suggests
- Standard advice on drinking limits.
About alcohol
The body breaks down alcohol in two steps: alcohol dehydrogenase turns ethanol into acetaldehyde, a toxic compound, and aldehyde dehydrogenase 2 turns acetaldehyde into harmless acetate.
Others in other substances
Compare all 7 other substancesDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.