Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Other substancesExample report

LSD

Acid

Use with caution

You clear this drug slowly, so its effects may be stronger and last longer. Starting with a lower dose may help avoid a bad experience.

The genes behind this label

The guidelines read one gene for LSD. Each card shows the two copies this person inherited and what they mean.

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What each guideline says about your result.

CYP2D6Poor metabolizer

Gene2Rx research summary

In plain words: You clear this drug slowly, so its effects may be stronger and last longer. Starting with a lower dose may help avoid a bad experience.
What it means: No functional CYP2D6. In the pooled analysis of 81 participants, poor metabolizers had longer LSD half-lives and about 75% higher area under the curve for LSD and for 2-oxo-3-hydroxy-LSD than carriers of functional CYP2D6, and reported greater alterations of mind and longer-lasting effects. In a separate analysis of 213 participants, acute anxiety was inversely correlated with genetically determined CYP2D6 function, although dose and pre-drug mood were much stronger predictors of the experience.
What the research suggests: Expect higher exposure and a longer duration of effect. In a research setting, consider a lower starting dose with gradual increases and a longer monitoring period.

LSD is a semi-synthetic ergoline that produces its effects by activating serotonin 5-HT2A receptors.

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.