CYP1A2Your two copies: *1/*30
Rapid metabolizer
One copy works normally and one works faster than usual.
Breaks down caffeine and some medicines, such as clozapine.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Other substancesExample report
Caffeine
Coffee, Tea
Use with caution
Caffeine may wear off slightly sooner for you than average. The usual advice on caffeine limits applies.
The genes behind this label
The guidelines read one gene for caffeine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP1A2Rapid metabolizer
Gene2Rx research summary
Evidence: moderateSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Caffeine may wear off slightly sooner for you than average. The usual advice on caffeine limits applies.
- What it means
- One rs762551 A allele (*1/*30). Modestly higher CYP1A2 activity, mainly in smokers. Note: in the coffee and cardiovascular literature, A/C carriers are classed as 'slow' metabolizers.
- What the research suggests
- Caffeine may be cleared somewhat faster than average. Standard advice on moderate intake applies.
Also an ingredient in
Caffeine is also in these combination products. The guidance above is for caffeine on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
- Acetaminophen and caffeineExcedrin Tension Headache, Excedrin Mild Headache, Excedrin Quick Tab, Panadol Extra
- Acetaminophen, aspirin and caffeineExcedrin, Anacin Advanced Headache Formula, Arthriten Inflammatory Pain, Backaid IPF, Pamprin Max Formula, Vanquish
- Acetaminophen, butalbital and caffeineFioricet, Capacet, Esgic, Repan, Vanatol, Vtol, Zebutal
- Acetaminophen, butalbital, caffeine and codeineFioricet with Codeine
- Acetaminophen, caffeine and pyrilamineMidol Complete
- Aspirin and caffeineAnacin, BC Arthritis, BC Original Formula, Stanback Headache Powder
- Aspirin, butalbital and caffeineFiorinal
- Aspirin, butalbital, caffeine and codeineAscomp
About caffeine
Caffeine is cleared almost entirely by one liver enzyme, CYP1A2.
Others in other substances
Compare all 7 other substancesDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.