CYP2B6Your two copies: *1/*1
Normal metabolizer
Both copies work normally.
Breaks down efavirenz, ketamine, methadone and some drugs for depression.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Other substancesExample report
Ketamine
Ketalar
Use as directed
Your body processes ketamine at the usual rate.
The genes behind this label
The guidelines read one gene for ketamine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2B6Normal metabolizer
Gene2Rx research summary
Evidence: strongSee the drug page (Gene2Rx research summaries, opens in a new tab)
- In plain words
- Your body processes ketamine at the usual rate.
- What it means
- Usual CYP2B6 activity and expected N-demethylation of ketamine to norketamine. CYP3A4 contributes to the same step, and the relative roles of the two enzymes are still debated.
- What the research suggests
- Initiate with standard ketamine doses per clinical practice and titrate to effect.
About ketamine
Ketamine is an anaesthetic that works by blocking the NMDA glutamate receptor, and it is also used at lower doses for pain and, off label or as the related medicine esketamine, for depression.
- Used for
- As the sole anaesthetic for procedures not needing muscle relaxation, for induction of anaesthesia and to supplement other anaesthetics. It is a Schedule III controlled substance and is also used non-medically.
Others in other substances
Compare all 7 other substancesDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.