ABCG2Your two copies: rs2231142G/rs2231142G
Normal function
Both copies work normally.
A pump that clears uric acid and some drugs, such as rosuvastatin, from the body.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cholesterol medicationsExample report
Rosuvastatin
Crestor
Use as directed
Your genes support the usual starting dose of this statin.
The genes behind this label
The guidelines read 2 genes for rosuvastatin. Each card shows the two copies this person inherited and what they mean.
SLCO1B1Your two copies: *15/*1A
Decreased function
One copy works and one works less well.
Moves statins into the liver.
This result doesn't change the label.
What the guidelines say
What each guideline says about your result.
ABCG2Normal functionSLCO1B1Decreased function
CPIC guideline, both genes together
Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your genes support the usual starting dose of this statin.
- What it means
- ABCG2: Typical myopathy risk and rosuvastatin exposure SLCO1B1: Increased rosuvastatin exposure as compared to normal function; Typical myopathy risk with doses ≤20 mg.
- What the guideline suggests
- Prescribe desired starting dose and adjust doses of rosuvastatin based on disease-specific and specific population guidelines. Prescriber should be aware of possible increased risk for myopathy especially for doses >20mg.
From the combined ABCG2 and SLCO1B1 table in CPIC's statin guideline.
CPIC reads your ABCG2 and SLCO1B1 results together for rosuvastatin, so this label reflects both genes.
Also an ingredient in
Rosuvastatin is also in these combination products. The guidance above is for rosuvastatin on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About rosuvastatin
Rosuvastatin (Crestor) is a statin that lowers LDL cholesterol and the risk of heart attack and stroke.
- Used for
- Reducing the risk of cardiovascular death, heart attack, stroke and artery-opening procedures in adults at increased risk; lowering LDL cholesterol in adults, and in children with familial hypercholesterolemia (from age 8, or age 7 for the homozygous form)
Others in cholesterol medications
Compare all 7 cholesterol medicationsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.