Drugs affected by ABCG2
About ABCG2
ABCG2 is a transporter that moves urate and several drugs out of cells. The Q141K variant (rs2231142) is common, particularly in East Asian populations, and reduces transporter function. Carriers tend to have higher serum urate and respond less to allopurinol, and the Dutch Pharmacogenetics Working Group advises a higher allopurinol dose for them.[1] ABCG2 also affects how quickly the body clears rosuvastatin.[2]
The DPWG advises 1.25 times the standard allopurinol dose for one copy of Q141K and 1.4 times for two.[1]
What we test for ABCG2
Gene2Rx uses definitions covering 2 named ABCG2 alleles, built from 1 variant in Gene2Rx definitions. Results depend on the variants available in your upload.
- Named alleles
- 2
- Defined variants
- 1
- Source
- Gene2Rx definitions
- Genome build
- GRCh38
- Normal Function 1
- Decreased Function 1
What do these allele names mean?
ABCG2 alleles are named by the underlying DNA variant rather than a star number. For example, c.61C>T describes a single base change at position 61 of the coding sequence.
DNA variant labels identify sequence differences. Their interpretation depends on the particular gene, the evidence, and the variants that can be assessed in your data. A DNA result does not directly measure enzyme activity.
The source of these definitions is listed above. Missing variants or incomplete coverage can leave a result indeterminate.
Medications with ABCG2 information
This list contains 2 medications with ABCG2 information from the sources shown below. Evidence and report eligibility differ by drug; each page explains its scope and limitations.
Brand products containing a ABCG2-affected ingredient
These branded medications include at least one active ingredient whose metabolism or action involves ABCG2. Each links to its full pharmacogenetic breakdown.
References
- European Journal of Human Genetics. Dutch Pharmacogenetics Working Group guideline for ABCG2, HLA-B and allopurinol (2024). pmc.ncbi.nlm.nih.gov
- CPIC. CPIC Guideline for Statins and SLCO1B1, ABCG2, and CYP2C9 (2022). cpicpgx.org
Explore ABCG2 in your report
Informational only, not medical advice. The presence of a ABCG2 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.