SLCO1B1Your two copies: *15/*1A
Decreased function
One copy works and one works less well.
Moves statins into the liver.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cholesterol medicationsExample report
Pravastatin
Pravachol
Use with caution
Your body may process this drug more slowly, so higher doses might carry added risks.
The genes behind this label
The guidelines read one gene for pravastatin. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
SLCO1B1Decreased function
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body may process this drug more slowly, so higher doses might carry added risks.
- What it means
- Increased pravastatin exposure compared with normal function; typical myopathy risk with doses ≤40 mg
- What the guideline suggests
- Prescribe desired starting dose and adjust doses of pravastatin based on disease-specific guidelines. Prescriber should be aware of possible increased risk for myopathy especially with doses >40 mg per day.
About pravastatin
Pravastatin (Pravachol) is a statin that lowers LDL cholesterol and the risk of heart attack and stroke.
- Used for
- Lowering LDL cholesterol in adults, and in children 8 and older with familial hypercholesterolemia; reducing heart attack, stroke, artery-opening procedures and cardiovascular death in adults with or without known coronary heart disease
Others in cholesterol medications
Compare all 7 cholesterol medicationsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.