CYP2C9Your two copies: *1/*2
Intermediate metabolizer
One copy works and one works less well.
1.5 activity scoreTypical: 2Clears warfarin, phenytoin, celecoxib and some other pain relievers.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cholesterol medicationsExample report
Fluvastatin
Lescol
Use with caution
Your genes make this statin build up in your blood, which can raise the risk of muscle problems. A lower starting dose or a dose limit is suggested.
The genes behind this label
The guidelines read 2 genes for fluvastatin. Each card shows the two copies this person inherited and what they mean.
SLCO1B1Your two copies: *15/*1A
Decreased function
One copy works and one works less well.
Moves statins into the liver.
This result changes the label.
What the guidelines say
What each guideline says about your result.
CYP2C9Intermediate metabolizer (activity score 1.5)SLCO1B1Decreased function
CPIC guideline, both genes together
Evidence: optionalRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your genes make this statin build up in your blood, which can raise the risk of muscle problems. A lower starting dose or a dose limit is suggested.
- What it means
- CYP2C9: Increased fluvastatin exposure as compared to normal metabolizer which may translate to increased myopathy risk. SLCO1B1: Increased fluvastatin exposure as compared to normal function; Typical myopathy risk with ≤40 mg.
- What the guideline suggests
- Prescribe ≤20mg per day as a starting dose and adjust doses of fluvastatin based on disease-specific guidelines. If dose >20mg needed for desired efficacy, consider an alternative statin or combination therapy (i.e., fluvastatin plus non-statin guideline directed medical therapy) (PMID: 30423391).
From the combined CYP2C9 and SLCO1B1 table in CPIC's statin guideline. CYP2C9 is matched on its activity score.
CPIC reads your CYP2C9 and SLCO1B1 results together for fluvastatin, so this label reflects both genes.
About fluvastatin
Fluvastatin (Lescol XL) is a statin that lowers LDL cholesterol.
- Used for
- Lowering LDL cholesterol in adults, and in children 10 and older with familial hypercholesterolemia; reducing the need for artery-opening procedures and slowing coronary atherosclerosis in adults with coronary heart disease
Others in cholesterol medications
Compare all 7 cholesterol medicationsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.