SLCO1B1Your two copies: *15/*1A
Decreased function
One copy works and one works less well.
Moves statins into the liver.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cholesterol medicationsExample report
Simvastatin
Zocor
Use with caution
More of this statin stays in your blood, so muscle side effects are more likely. Your doctor may use a different statin or a lower dose.
The genes behind this label
The guidelines read one gene for simvastatin. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
SLCO1B1Decreased function
CPIC guideline
Use with caution Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- More of this statin stays in your blood, so muscle side effects are more likely. Your doctor may use a different statin or a lower dose.
- What it means
- Increased simvastatin acid exposure compared with normal function; increased risk of muscle side effects (myopathy)
- What the guideline suggests
- Prescribe an alternative statin depending on desired potency. Low-risk options: atorvastatin 10 to 20 mg, pitavastatin 1 mg, pravastatin 40 mg, rosuvastatin 5 to 10 mg. Moderate-risk options: fluvastatin 80 mg, pitavastatin 2 mg, pravastatin 80 mg. High-risk options (use with caution): lovastatin 40 to 80 mg, pitavastatin 4 mg, simvastatin 20 to 40 mg. If simvastatin is used, limit dose to <20 mg/day.
FDA drug label
Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body clears simvastatin more slowly than normal, causing it to build up in your system. This raises your risk of muscle pain or damage, especially at higher doses.
- What it means
- Results in higher systemic concentrations and higher adverse reaction risk (myopathy). The risk of adverse reaction (myopathy) is higher for patients on 80 mg than for those on lower doses.
- What the label suggests
- No specific dosing change in the FDA table. The risk of myopathy is higher at 80 mg than at lower doses.
Also an ingredient in
Simvastatin is also in these combination products. The guidance above is for simvastatin on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About simvastatin
Simvastatin (Zocor) is a statin that lowers LDL cholesterol and the risk of heart attack and stroke.
- Used for
- Lowering LDL cholesterol in adults, and in children 10 and older with familial hypercholesterolemia; reducing the risk of death, heart attack and stroke in adults at high risk of coronary heart disease
Others in cholesterol medications
Compare all 7 cholesterol medicationsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.