SLCO1B1Your two copies: *15/*1A
Decreased function
One copy works and one works less well.
Moves statins into the liver.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cholesterol medicationsExample report
Atorvastatin
Lipitor
Use with caution
More of this statin stays in your blood, which can raise the chance of muscle side effects. Your doctor may limit the dose.
The genes behind this label
The guidelines read one gene for atorvastatin. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
SLCO1B1Decreased function
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- More of this statin stays in your blood, which can raise the chance of muscle side effects. Your doctor may limit the dose.
- What it means
- Increased atorvastatin exposure as compared with normal function, which may translate to increased myopathy risk.
- What the guideline suggests
- Prescribe ≤40 mg as a starting dose and adjust doses of atorvastatin based on disease-specific guidelines. Prescriber should be aware of possible increased risk for myopathy especially for the 40-mg dose. If dose >40 mg is needed for desired efficacy, consider combination therapy (i.e., atorvastatin plus nonstatin guideline-directed medical therapy).
Also an ingredient in
Atorvastatin is also in these combination products. The guidance above is for atorvastatin on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About atorvastatin
Atorvastatin (Lipitor) is a statin that lowers LDL cholesterol and the risk of heart attack and stroke; in 2018 it was the most commonly prescribed drug in the United States.
- Used for
- Lowering LDL cholesterol in adults, and in children 10 and older with familial hypercholesterolemia; reducing heart attack, stroke and related events in adults with, or at risk of, coronary heart disease
Others in cholesterol medications
Compare all 7 cholesterol medicationsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.