SLCO1B1Your two copies: *15/*1A
Decreased function
One copy works and one works less well.
Moves statins into the liver.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cholesterol medicationsExample report
Lovastatin
Mevacor
Consider alternative
Your genes make this statin build up in your blood, which may raise your risk of muscle problems. A different statin, or a low dose of this one, is often suggested.
The genes behind this label
The guidelines read one gene for lovastatin. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
SLCO1B1Decreased function
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your genes make this statin build up in your blood, which may raise your risk of muscle problems. A different statin, or a low dose of this one, is often suggested.
- What it means
- Increased lovastatin acid exposure as compared with normal function, which may translate to increased myopathy risk
- What the guideline suggests
- Consider prescribing a lower-risk alternative such as atorvastatin (10 to 20 mg), pravastatin (40 mg), or rosuvastatin (5 to 10 mg). If lovastatin is warranted, limit the dose to ≤20 mg/day to reduce the risk of muscle-related side effects.
About lovastatin
Lovastatin (Mevacor) is a statin that lowers LDL cholesterol and the risk of heart attack.
- Used for
- Lowering LDL cholesterol in adults, and in adolescents with familial hypercholesterolemia; reducing heart attacks, unstable angina and artery-opening procedures in adults without symptomatic cardiovascular disease; slowing coronary atherosclerosis in people with coronary heart disease
Others in cholesterol medications
Compare all 7 cholesterol medicationsDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.