CYP2C9Your two copies: *1/*2
Intermediate metabolizer
One copy works and one works less well.
1.5 activity scoreTypical: 2Clears warfarin, phenytoin, celecoxib and some other pain relievers.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Pain managementExample report
Piroxicam
Feldene
Use with caution
Your body breaks down piroxicam more slowly than normal, which can cause higher drug levels. Your doctor may need to adjust your dosing.
The genes behind this label
The guidelines read one gene for piroxicam. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C9Intermediate metabolizer (activity score 1.5)
CPIC guideline
Use as directed Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body slows the drug slightly, but the usual starting dose is still fine.
- What it means
- Mildly reduced metabolism
- What the guideline suggests
- Initiate therapy with recommended starting dose. In accordance with the prescribing information, use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
FDA drug label
Use with caution See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down piroxicam more slowly than normal, which can cause higher drug levels. Your doctor may need to adjust your dosing.
- What it means
- Results in higher systemic concentrations.
- What the label suggests
- No specific dosing change for intermediate metabolizers. Refer to FDA labeling.
About piroxicam
Piroxicam (Feldene) is a long-acting prescription nonsteroidal anti-inflammatory drug (NSAID) taken once a day for osteoarthritis and rheumatoid arthritis.
- Used for
- Osteoarthritis and rheumatoid arthritis
Others in pain management
Compare all 13 pain managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.