CYP2C9Your two copies: *1/*2
Intermediate metabolizer
One copy works and one works less well.
1.5 activity scoreTypical: 2Clears warfarin, phenytoin, celecoxib and some other pain relievers.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Pain managementExample report
Celecoxib
Celebrex
Use as directed
Your body slows the drug down slightly, but usually the normal starting dose is fine.
The genes behind this label
The guidelines read one gene for celecoxib. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C9Intermediate metabolizer (activity score 1.5)
CPIC guideline
Use as directed Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body slows the drug down slightly, but usually the normal starting dose is fine.
- What it means
- Mildly reduced metabolism
- What the guideline suggests
- Initiate therapy with recommended starting dose. In accordance with the prescribing information, use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
FDA drug label
Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your CYP2C9 result means somewhat lower CYP2C9 activity than usual, but the FDA gives no genetic dosing change for celecoxib at this result.
- What it means
- No FDA guidance for your genotype
- What the label suggests
- Initiate therapy with recommended starting dose.
Also an ingredient in
Celecoxib is also in these combination products. The guidance above is for celecoxib on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About celecoxib
Celecoxib (Celebrex) is a prescription nonsteroidal anti-inflammatory drug (NSAID) used for arthritis, acute pain and menstrual cramps.
- Used for
- Osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (age 2 and older), ankylosing spondylitis, acute pain in adults and menstrual cramps (primary dysmenorrhea). Elyxyb is for acute migraine in adults.
Others in pain management
Compare all 13 pain managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.