CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Pain managementExample report
Hydrocodone
Hysingla ER
Use with caution
Your body makes less of hydrocodone's stronger active form. It's not clear this changes pain relief, so the usual dose is recommended, with a different pain medicine to consider if it doesn't work.
The genes behind this label
The guidelines read one gene for hydrocodone. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
CPIC guideline
Evidence: optionalRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body makes less of hydrocodone's stronger active form. It's not clear this changes pain relief, so the usual dose is recommended, with a different pain medicine to consider if it doesn't work.
- What it means
- Decreased metabolism of hydrocodone to active metabolite, hydromorphone, but there is insufficient evidence to determine if these effects on pharmacokinetics translate into decreased analgesia or side effects.
- What the guideline suggests
- Use hydrocodone label recommended age- or weight-specific dosing. If no response and opioid use is warranted, consider non-codeine and non-tramadol opioid.
Also an ingredient in
Hydrocodone is also in these combination products. The guidance above is for hydrocodone on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About hydrocodone
Hydrocodone is a prescription opioid for pain severe enough to need one, and in some syrups and tablets for cough in adults.
- Used for
- Pain severe enough to need an opioid when other treatments are not enough; cough in adults 18 and older (hydrocodone and homatropine)
Others in pain management
Compare all 13 pain managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.