CYP2C9Your two copies: *1/*2
Intermediate metabolizer
One copy works and one works less well.
1.5 activity scoreTypical: 2Clears warfarin, phenytoin, celecoxib and some other pain relievers.
This result doesn't change the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Pain managementExample report
Ibuprofen
Advil
Use as directed
Your body slows the drug down slightly, but usually the normal starting dose is fine.
The genes behind this label
The guidelines read one gene for ibuprofen. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C9Intermediate metabolizer (activity score 1.5)
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body slows the drug down slightly, but usually the normal starting dose is fine.
- What it means
- Mildly reduced metabolism
- What the guideline suggests
- Initiate therapy with recommended starting dose. In accordance with the prescribing information, use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
Also an ingredient in
Ibuprofen is also in these combination products. The guidance above is for ibuprofen on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
- Acetaminophen and ibuprofenAdvil Dual Action, Combogesic
- Chlorpheniramine, ibuprofen and phenylephrineAdvil Allergy and Congestion Relief, Advil Multi-Symptom Cold and Flu
- Chlorpheniramine, ibuprofen and pseudoephedrineAdvil Allergy Sinus
- Diphenhydramine and ibuprofenAdvil PM, Motrin PM
- Famotidine and ibuprofenDuexis
- Hydrocodone and ibuprofenVicoprofen, Ibudone, Reprexain
- Ibuprofen and phenylephrineAdvil Sinus Congestion and Pain, Sudafed PE Head Congestion Plus Pain
- Ibuprofen and pseudoephedrineAdvil Cold and Sinus
About ibuprofen
Ibuprofen (Advil, Motrin IB) is a nonsteroidal anti-inflammatory drug (NSAID) sold over the counter for pain and fever, and by prescription for arthritis, pain and menstrual cramps.
- Used for
- Over the counter: minor aches and pains (headache, toothache, back pain, menstrual cramps, colds, muscle aches, minor arthritis pain) and fever. By prescription: rheumatoid arthritis, osteoarthritis, mild to moderate pain and menstrual cramps.
Others in pain management
Compare all 13 pain managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.