CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cardiovascular · CardiomyopathyExample report
Mavacamten
Camzyos
Use with caution
Your body breaks down mavacamten slightly slower than normal, which may lead to higher drug levels. Your doctor will monitor you closely and adjust the dose based on your response.
The genes behind this label
The guidelines read one gene for mavacamten. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizer
FDA drug label
Evidence: moderateSee the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body breaks down mavacamten slightly slower than normal, which may lead to higher drug levels. Your doctor will monitor you closely and adjust the dose based on your response.
- What it means
- Results in higher systemic concentrations and may have higher adverse reaction risk (heart failure). Dosage is based on individual response. The dose titration and monitoring schedule accounts for differences due to CYP2C19 genetic variation, so adjustments based on CYP2C19 genotype are not necessary. Refer to FDA labeling for specific dosing recommendations and monitoring.
- What the label suggests
- Follow the label's dose titration and monitoring schedule; no genotype-based adjustment is needed.
About mavacamten
Mavacamten (Camzyos) is a cardiac myosin inhibitor for symptomatic obstructive hypertrophic cardiomyopathy (HCM).
- Used for
- Symptomatic obstructive hypertrophic cardiomyopathy in adults and children weighing 30 kg or more
Others in cardiovascular
Compare all 7 cardiovascularDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.