CYP2C19Your two copies: *1/*2
Intermediate metabolizer
One copy works and one doesn't.
Handles several SSRIs, acid reducers such as omeprazole, and the blood thinner clopidogrel.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cardiovascular · Blood ThinnersExample report
Clopidogrel
Plavix
Consider alternative
Your body turns this drug into its active form more slowly, so it may not protect you as well. A different blood thinner is usually suggested.
The genes behind this label
The guidelines read one gene for clopidogrel. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2C19Intermediate metabolizer
CPIC guideline
Consider alternative Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body turns this drug into its active form more slowly, so it may not protect you as well. A different blood thinner is usually suggested.
- What it means
- Reduced clopidogrel active metabolite formation; increased on-treatment platelet reactivity; increased risk for adverse cardiac and cerebrovascular events
- What the guideline suggests
- Avoid standard dose (75 mg) clopidogrel if possible. Use prasugrel or ticagrelor at standard dose if no contraindication
FDA drug label
Consider alternative Evidence: moderateSee the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- This drug may not work as well for you, which can raise the risk of heart problems. Your doctor may use a different drug to prevent clots.
- What it means
- Results in lower systemic active metabolite concentrations, lower antiplatelet response, and may result in higher cardiovascular risk. Consider use of another platelet P2Y12 inhibitor.
- What the label suggests
- Results in lower systemic active metabolite concentrations, lower antiplatelet response, and may result in higher cardiovascular risk. Consider use of another platelet P2Y12 inhibitor.
About clopidogrel
Clopidogrel (Plavix) is an antiplatelet medicine taken to lower the risk of heart attack and stroke, most often after an acute coronary syndrome or a coronary stent.
- Used for
- Lowering the risk of heart attack and stroke after an acute coronary syndrome (given with aspirin), and in people with a recent heart attack, a recent stroke or peripheral arterial disease. Widely used after coronary stenting.
Others in cardiovascular
Compare all 7 cardiovascularDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.