NAT2Your two copies: *16/*5
Poor metabolizer
Both copies work less well.
Breaks down hydralazine, isoniazid and some other drugs.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cardiovascular · AntihypertensivesExample report
Hydralazine
Apresoline
Use with caution
Your body breaks down hydralazine slowly, which means you need a lower starting dose. Higher doses may increase side effects, including a rare immune reaction.
The genes behind this label
The guidelines read one gene for hydralazine. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
NAT2Poor metabolizer
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body breaks down hydralazine slowly, which means you need a lower starting dose. Higher doses may increase side effects, including a rare immune reaction.
- What it means
- Predicted to have increased hydralazine plasma concentrations compared to NAT2 rapid and intermediate metabolizers, which may lead to both increased efficacy and adverse effects, including drug-induced systemic lupus erythematosus.
- What the guideline suggests
- Initiate therapy at a total daily dose of 40 to 75 mg. Carefully titrate dose upward to clinical effect or guideline-recommended dose; use caution with total daily hydralazine doses of 200 mg or more.
Also an ingredient in
Hydralazine is also in these combination products. The guidance above is for hydralazine on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About hydralazine
Hydralazine is a blood vessel relaxant used mainly for hypertension that has not responded to other medicines, and with isosorbide dinitrate for heart failure.
- Used for
- High blood pressure, especially resistant hypertension; heart failure with isosorbide dinitrate
Others in cardiovascular
Compare all 7 cardiovascularDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.