CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Cardiovascular · Beta BlockersExample report
Metoprolol
Lopressor, Toprol XL
Use with caution
Your body clears this drug very slowly, so it can build up. Your doctor may start with the lowest dose and watch your heart rate.
The genes behind this label
The guidelines read one gene for metoprolol. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer (activity score 0.0)
CPIC guideline
Evidence: moderateRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body clears this drug very slowly, so it can build up. Your doctor may start with the lowest dose and watch your heart rate.
- What it means
- Decreased metabolism of metoprolol leading to markedly increased drug concentrations; this leads to greater heart rate and blood pressure reductions. The effect on clinical outcomes is unclear.
- What the guideline suggests
- Initiate therapy with the lowest recommended starting dose. Carefully titrate dose upward to clinical effect or guideline-recommended dose; monitor more closely for bradycardia. Alternatively, consider selecting another beta-blocker.
Also an ingredient in
Metoprolol is also in these combination products. The guidance above is for metoprolol on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About metoprolol
Metoprolol is a beta-blocker, sold as Lopressor, Toprol-XL and generics, that is used for high blood pressure, angina, heart failure and after a heart attack.
- Used for
- High blood pressure and angina (both forms); heart failure (extended release); treatment after a heart attack (immediate release)
Others in cardiovascular
Compare all 7 cardiovascularDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.