Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report

Cardiovascular · Beta BlockersExample report

Carvedilol

Coreg, Coreg CR

Use with caution

Your body breaks down carvedilol much more slowly than normal, causing the drug to build up in your system. This increases your risk of dizziness and other side effects.

The genes behind this label

The guidelines read one gene for carvedilol. Each card shows the two copies this person inherited and what they mean.

CYP2D6*4/*4

Poor metabolizer

Neither copy works.

0.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Poor metabolizer

FDA drug label

See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body breaks down carvedilol much more slowly than normal, causing the drug to build up in your system. This increases your risk of dizziness and other side effects.
What it means: Results in higher systemic concentrations and higher adverse reaction risk (dizziness).
What the label suggests: No specific dosing change in the FDA table. Refer to FDA labeling.

About carvedilol

Carvedilol (Coreg, Coreg CR and generics) is a beta-blocker that also blocks alpha-1 receptors, used for heart failure, for a weak heart pump after a heart attack, and for high blood pressure.

Used for: Chronic heart failure; reduced heart pumping function after a heart attack; high blood pressure

Others in cardiovascular

Compare all 7 cardiovascular

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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