Genera Pharmacogenetics: Turn Your Genera Raw Data Into a Drug Response Report

Genera (genera.com.br) is a Brazilian consumer genetics service that reads your DNA on a genotyping array and lets you download the raw data, the file it calls dados brutos. What Genera does not give you is a guideline-based report on how those genes affect your medications. That is what Gene2Rx adds. Upload your Genera raw data file and Gene2Rx turns it into a pharmacogenetics report covering 110 medications, built on the same CPIC and FDA guidelines clinicians use. It runs in minutes, costs $5 for a starter report or $49 for the full report, needs no doctor's order, and never expires, because your DNA does not change. You already paid to have your DNA read; this unlocks the part of it that affects prescriptions.

Genera's genotyping array reads hundreds of thousands of positions across every chromosome, including many of the pharmacogenetic variants used in clinical testing: the markers for CYP2D6, CYP2C19, CYP2C9, SLCO1B1, VKORC1, DPYD, and more are sitting in your dados brutos file. The genotype calls are already there, on the standard GRCh37 reference our pipeline expects, at a marker density comparable to 23andMe and AncestryDNA. Genera simply does not interpret most of these positions for drug response. What is missing is the analysis that turns them into per-medication guidance.

Gene2Rx reads your raw data, calls your metabolizer phenotype for each pharmacogene (poor, intermediate, normal, rapid, or ultrarapid), and maps each phenotype to specific recommendations for 110 medications, with every recommendation traceable to its CPIC or FDA guideline. The report spans psychiatry (antidepressants, antipsychotics, ADHD medications), cardiology (clopidogrel, warfarin, statins, metoprolol), pain (codeine, tramadol), chemotherapy (capecitabine, fluorouracil), transplant, and gastrointestinal drugs. It is delivered in minutes, no new sample and no prescriber required.

It is worth being clear about the limits. Genera, like 23andMe and AncestryDNA, runs a consumer genotyping array rather than a clinical-grade assay, and the raw data download is not intended for medical use. It reads only the specific positions printed on the chip, so it does not detect structural variants such as gene duplications and deletions. That matters most for CYP2D6,^[1] where an extra gene copy can make someone an ultrarapid metabolizer and a deleted copy can leave almost no enzyme. For most prescribing questions your Genera data is a strong, low-cost starting point; for a high-stakes, one-time decision such as chemotherapy dosing, a clinician may still confirm a key result with a clinical-grade test.

Genera's consumer reports focus on ancestry, traits, and health predisposition, framed as wellness information. They do not give you guideline-based recommendations across your medication list. Gene2Rx reads the pharmacogenetic variants out of the same raw file and reports against 110 medications using CPIC and FDA dosing guidance, the way a clinical pharmacogenetic report reads.

Clinical pharmacogenetic tests run from a few hundred to a few thousand dollars, need a new DNA sample, and require a provider order. Because you already have Genera data, none of that applies: a Gene2Rx report is $5 for the starter tier, $35 for a psychiatric report, or $49 for the full 110-medication report, with no lab work to repeat. Your pharmacogenetic profile does not change over time, so a single report is a reference you will use for decades of prescribing decisions.

These are the main genes Gene2Rx reads out of your Genera data and what each one affects. The biology is the same no matter which data source you start from; what Genera provides is the raw genotype at these positions.

Your Genera raw data contains the genotypes for all of these genes; the only thing standing between that and actionable guidance is interpretation. Gene2Rx translates your genotypes into metabolizer phenotypes for each gene, then maps those phenotypes to specific medication recommendations anchored to CPIC^[1] and FDA^[9] guidelines, so the output reads the same way a clinical pharmacogenetic report would.

If you already have Genera data, there is little reason to wait: the data exists and the starter report is $5. It is most valuable if you are starting or already taking a medication with pharmacogenetic guidelines, if you have had side effects or poor response in the past, or if you simply want the information on file for future prescribing. Because your genotype never changes, one report serves you for life.

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Not in a prescribing sense. Genera's consumer reports focus on ancestry, traits, and health predisposition, framed as wellness information. Gene2Rx reads the pharmacogenetic variants out of the same raw data file (dados brutos) and reports against 110 medications with CPIC and FDA guideline-based recommendations.

For the common variants, yes. Genera's genotyping array captures the pharmacogenetic markers that drive the majority of actionable recommendations, at a density comparable to 23andMe and AncestryDNA, on the standard GRCh37 reference our pipeline uses. Two caveats are worth knowing: it is a consumer-grade product whose raw data is not intended for medical use rather than a clinical-grade assay, and like all genotyping chips it does not detect structural variants such as CYP2D6 gene duplications or deletions. For the most complete picture, whole genome sequencing resolves more (and Gene2Rx accepts that too), and a clinician may confirm a high-stakes result with a clinical-grade test.

Log in to your Genera account at genera.com.br and download your raw data, labeled dados brutos. It is a .csv file with columns for the marker ID, chromosome, position, and genotype. Upload that file to Gene2Rx exactly as downloaded; there is no need to edit or convert it.

Those work too. Gene2Rx accepts Genera, 23andMe, AncestryDNA, and MyHeritage raw data, plus VCF files from whole genome sequencing. The process is the same: download your raw data and upload it. WGS and VCF uploads carry a $15 surcharge because they take more processing.