Drugs affected by NUDT15
About NUDT15
NUDT15 helps limit the cellular effects of active thiopurine metabolites. Reduced function increases susceptibility to thiopurine toxicity. Interpret the result alongside TPMT for azathioprine, mercaptopurine, and thioguanine.[1]
A typical result in one gene does not cancel a reduced-function result in the other. An unresolved combined interpretation retains available per-gene information and its limitations.
What we test for NUDT15
Gene2Rx uses definitions covering 23 named NUDT15 star alleles, built from 21 variants in Gene2Rx definitions. Results depend on the variants available in your upload.
- Star alleles
- 23
- Defined variants
- 21
- Source
- Gene2Rx definitions
- Genome build
- GRCh38
- Normal Function 1
- Decreased Function 2
- No Function 12
- Uncertain Function 6
- Unknown Function 2
Notable NUDT15 alleles
-
*1 Normal Function
Reference allele — normal NUDT15 activity.
-
*3 No Function
The most common no-function allele in East Asian populations; carriers are highly sensitive to thiopurines.
~10% in East Asians
What are star alleles?
Star alleles (like *1, *2, *4) are standardized names for distinct versions of a pharmacogene. *1 is the reference; other numbers identify distinct allele definitions. A higher number does not mean lower function.
You inherit one allele from each parent, so your genotype is a pair (e.g. *1/*4). The pair determines your predicted phenotype: for example, whether you metabolize a drug at a normal, decreased, or no-function rate.
PharmVar is the international registry that defines and curates these allele names. Gene2Rx uses the supported definitions summarized here. Coverage depends on the variants present in your input; this is not a guarantee that every cataloged allele can be identified.
Medications with NUDT15 information
This list contains 3 medications with NUDT15 information from the sources shown below. Evidence and report eligibility differ by drug; each page explains its scope and limitations.
Brand products containing a NUDT15-affected ingredient
These branded medications include at least one active ingredient whose metabolism or action involves NUDT15. Each links to its full pharmacogenetic breakdown.
References
- CPIC. CPIC: TPMT/NUDT15 thiopurine guideline, 2025 update (2026). pmc.ncbi.nlm.nih.gov
Explore NUDT15 in your report
Informational only, not medical advice. The presence of a NUDT15 pharmacogenetic guideline does not mean every patient needs to change their dose. Never start, stop, or change a medication without talking to your prescribing clinician.