CYP2D6Your two copies: *4/*4
Poor metabolizer
Neither copy works.
0.0 activity scoreTypical: 1.25 to 2.25Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.
This result changes the label.
Example report. Made from Leslie Knope's DNA data so you can see what yours will look like. Get your own report
Pain managementExample report
Tramadol
Ultram, ConZip
Consider alternative
Your body can't turn this drug into its active form well, so it may not relieve your pain. A different pain medicine is advised.
The genes behind this label
The guidelines read one gene for tramadol. Each card shows the two copies this person inherited and what they mean.
What the guidelines say
What each guideline says about your result.
CYP2D6Poor metabolizer
CPIC guideline
Consider alternative Evidence: strongRead the guideline (Clinical Pharmacogenetics Implementation Consortium, opens in a new tab)
- In plain words
- Your body can't turn this drug into its active form well, so it may not relieve your pain. A different pain medicine is advised.
- What it means
- Greatly reduced O-desmethyltramadol (active metabolite) formation leading to diminished analgesia.
- What the guideline suggests
- Avoid tramadol use because of possibility of diminished analgesia. If opioid use is warranted, consider a non-codeine opioid.
FDA drug label
Use with caution Evidence: moderateSee the FDA table (U.S. Food and Drug Administration, opens in a new tab)
- In plain words
- Your body turns this drug into its active form slowly, so it may not relieve pain as well. Your doctor may check how well it works.
- What it means
- Results in lower systemic active metabolite concentrations and may result in reduced efficacy.
- What the label suggests
- The FDA notes reduced efficacy but gives no dosing change. Monitor for adequate pain relief.
Also an ingredient in
Tramadol is also in these combination products. The guidance above is for tramadol on its own. What this person's genes mean for a combination is less clear, so if someone takes one, it's worth talking over with a prescriber or pharmacist.
About tramadol
Tramadol is a prescription pain medicine with two actions: it is a weak opioid, and it slows the reuptake of serotonin and norepinephrine.
- Used for
- Pain in adults that is severe enough to need an opioid and for which other treatments are not enough
Others in pain management
Compare all 13 pain managementDon't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.