Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Zuclopenthixol

Clopixol

Use with caution

Your body clears this drug faster than usual, so it may not work as well. If it doesn't, your doctor may raise the dose or try a different drug.

The genes behind this label

The guidelines read one gene for zuclopenthixol. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your body clears this drug faster than usual, so it may not work as well. If it doesn't, your doctor may raise the dose or try a different drug.
What it means: Increased CYP2D6 activity accelerates zuclopenthixol conversion, which can reduce plasma concentration and risk ineffectiveness.
What the guideline suggests: Insufficient data to make a firm dosage recommendation. If effectiveness is insufficient, try a dose increase, but do not exceed 1.5 times the normal dose. Alternatively, consider an antipsychotic that is not metabolised (or to a lesser extent) by CYP2D6 (e.g., flupentixol, quetiapine, olanzapine, clozapine).

About zuclopenthixol

Zuclopenthixol (Clopixol) is a first-generation antipsychotic of the thioxanthene type, used for psychoses, especially schizophrenia.

Used for: Psychoses, especially schizophrenia (not approved in the US)

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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