Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Brexpiprazole

Rexulti

Use as directed

Your body clears brexpiprazole a little faster, but there is no sign this makes it work less well. No dose change is needed.

The genes behind this label

The guidelines read one gene for brexpiprazole. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Use as directed Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your body clears brexpiprazole a little faster, but there is no sign this makes it work less well. No dose change is needed.
What it means: Increased CYP2D6 activity lowers exposure to brexpiprazole, but there are no indications that this reduces effectiveness.
What the guideline suggests: No action is required. Use standard brexpiprazole dosing.

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body processes brexpiprazole faster than most people, but there is no specific FDA guidance for your genotype. The standard dose is typically used.
What it means: No FDA guidance for your genotype
What the label suggests: Initiate therapy with recommended starting dose.

About brexpiprazole

Brexpiprazole (Rexulti) is an antipsychotic used for schizophrenia, as an add-on treatment for depression, and for agitation in Alzheimer's dementia.

Used for: Schizophrenia (adults and adolescents 13 and older); add-on treatment for major depressive disorder in adults; agitation associated with dementia due to Alzheimer's disease

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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