Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Haloperidol

Haldol

Use with caution

Your body clears this drug faster, so the usual dose may not work as well. A higher dose or a different drug is often suggested.

The genes behind this label

The guidelines read one gene for haloperidol. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result changes the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your body clears this drug faster, so the usual dose may not work as well. A higher dose or a different drug is often suggested.
What it means: Increased CYP2D6 activity leads to accelerated conversion of haloperidol. Plasma concentration is approximately 40% lower than in Normal Metabolizers, risking reduced effectiveness.
What the guideline suggests: Use 1.5 times the normal dose, or choose an alternative. Antipsychotics not metabolised (or metabolised to a much lesser extent) by CYP2D6 include flupentixol, penfluridol, quetiapine, olanzapine, or clozapine.

About haloperidol

Haloperidol (Haldol) is a first-generation antipsychotic used for psychotic disorders and for the tics of Tourette's disorder.

Used for: Psychotic disorders, including schizophrenia; tics and vocal utterances of Tourette's disorder; some severe behavior problems in children

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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