Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Pimozide

Orap

Use as directed

Your body may clear pimozide a little faster, but there is no evidence it works less well. No dose change is needed.

The genes behind this label

The guidelines read one gene for pimozide. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Use as directed Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your body may clear pimozide a little faster, but there is no evidence it works less well. No dose change is needed.
What it means: Increased CYP2D6 activity can lower pimozide concentrations, but there is no evidence of reduced effectiveness.
What the guideline suggests: No action is required. Use standard pimozide dosing.

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your CYP2D6 result means higher CYP2D6 activity than usual, but the FDA gives no genetic dosing change for pimozide at this result.
What it means: No FDA guidance for your genotype
What the label suggests: Initiate therapy with recommended starting dose.

About pimozide

Pimozide (Orap) is an antipsychotic used in the US to suppress motor and vocal tics in Tourette's disorder when standard treatment has not worked.

Used for: Suppressing motor and phonic tics in Tourette's disorder that has not responded to standard treatment

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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