Example report. The whole genome example: a public genome from the 1000 Genomes Project, with CYP2D6 Structural Analysis, so you can see what yours will look like. Get your own report

AntipsychoticsExample report

Aripiprazole

Abilify

Use as directed

Your body clears aripiprazole a little faster, but there is no evidence this makes it work less well. No dose change is needed.

The genes behind this label

The guidelines read one gene for aripiprazole. Each card shows the two copies this person inherited and what they mean.

CYP2D6*2/*2x2

Ultrarapid metabolizer

One copy works normally and one works faster than usual.

3.0 activity scoreTypical: 1.25 to 2.25

Turns on or clears about 1 in 4 prescription drugs. These include many drugs for depression, pain and ADHD.

This result doesn't change the label.

What the guidelines say

What each guideline says about your result.

CYP2D6Ultrarapid metabolizer

DPWG guideline

Use as directed Evidence: moderateRead the guideline (Dutch Pharmacogenetics Working Group, opens in a new tab)

In plain words: Your body clears aripiprazole a little faster, but there is no evidence this makes it work less well. No dose change is needed.
What it means: Increased CYP2D6 activity lowers the combined blood level of aripiprazole and its active metabolite dehydroaripiprazole to a limited degree. There is no evidence that this reduces effectiveness.
What the guideline suggests: No action is required. Use standard aripiprazole dosing.

FDA drug label

Use as directed See the FDA table (U.S. Food and Drug Administration, opens in a new tab)

In plain words: Your body processes aripiprazole faster than normal. The standard dose should work as expected.
What it means: No FDA guidance for your genotype
What the label suggests: Initiate therapy with recommended starting dose.

About aripiprazole

Aripiprazole (Abilify) is an antipsychotic used for schizophrenia, bipolar mania, Tourette's disorder and irritability in autism, and as an add-on treatment for depression.

Used for: Schizophrenia; manic and mixed episodes of bipolar I disorder; add-on treatment for major depressive disorder; irritability with autistic disorder; Tourette's disorder. The injections are for schizophrenia and maintenance treatment of bipolar I disorder in adults.

Others in antipsychotics

Compare all 12 antipsychotics

And 3 more

Don't change a dose on your own. Bring this report to your prescriber or pharmacist. They can weigh it with everything else they know about you.

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